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BioLegend 598904 Recombinant H

uman IL-17E (carrier-free)
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  • 2025年11月10日
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    北京云肽生物科技有限公司
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    • 英文名：

      Recombinant Human IL-17E (carrier-free)

    • 供应商：

      北京云肽生物科技有限公司

    BioLegend 598904 Recombinant Human IL-17E (carrier-free)

    北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。

    美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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    BioLegend 598904 Recombinant Human IL-17E (carrier-free)
    产品简介：
    产品品牌：BioLegend
    产品货号：598904
    产品名称：BioLegend 598904 Recombinant Human IL-17E (carrier-free)
    产品规格：25 µg

    产品说明：
    Regulatory Status  RUO
    Other Names  IL-25

    描述
    IL-17E，也称为IL-25，促进Th2偏向性免疫反应。这与促进Th1和Th17偏向性炎症的其他IL-17家族成员形成对比。IL-17E是过敏反应和保护肠道免受寄生虫感染的重要介质。在蠕虫感染和过敏反应期间，IL-17E的产生在肠道细胞、气道上皮细胞、特应性皮炎皮肤病变、局部Th2细胞、嗜酸性粒细胞和嗜碱性粒细胞中局部上调。它与IL-17RB结合，但也需要IL-17RA发挥其活性。IL-17E作用于多种细胞类型，这些细胞类型的反应是Th2细胞因子的产生增加以及Th1和Th17细胞因子的生成减少。气道IL-17E可被MMP7激活，MMP7是一种蛋白酶，在过敏原暴露时在气道上皮上调。切割的IL-17E显示出与IL-17RB的结合增强和Th2细胞因子的更强诱导。Th2细胞因子反过来触发Th2记忆细胞和抗炎M2巨噬细胞的扩增，增加嗜酸性粒细胞的动员和活化，以及树突状细胞的迁移。这些作用促进了保护性的抗蠕虫免疫反应以及过敏性炎症和气道高反应性。IL-17E还促进血管内皮细胞增殖和组装成管状结构。它还支持血脑屏障的完整性，并限制CD4+T细胞向大脑的渗透。
    IL-17E, also known as IL-25, promotes Th2 biased immune responses. This is in contrast to other IL-17 family members which promote Th1 and Th17 biased inflammation. IL-17E is an important mediator of allergic reactions and protection against intestinal parasites. During helminth infections and allergic reactions, IL-17E production is locally upregulated in intestinal cells, airway epithelial cells, atopic dermatitis skin lesions, local Th2 cells, eosinophils, and basophils. It binds to IL-17RB but also requires IL-17RA to exert its activity. IL-17E acts on a variety of cell types which respond with increased production of Th2 cytokines and reduced production of Th1 and Th17 cytokines. Airway IL-17E can be activated by MMP7, a protease that is upregulated in airway epithelium in response to allergen exposure. Cleaved IL-17E shows enhanced binding to IL-17RB and stronger induction of Th2 cytokines. The Th2 cytokines, in turn, trigger the expansion of Th2 memory cells and anti-inflammatory M2 macrophages, increased eosinophil mobilization and activation, and dendritic cell migration. These actions promote protective anti-helminth immune responses as well as allergic inflammation and airway hyperreactivity. IL-17E also promotes vascular endothelial cell proliferation and assembly into tubular structures. It also supports the integrity of the blood brain barrier and limits CD4+ T cell infiltration into the brain.

    Product Details
    Source
    Human IL-17E, amino acids (Tyr33-Gly177) with an additional Met at the N-terminus (Accession# NP_073626.1), was expressed in E. coli.

    Molecular Mass
    The 146 amino acid recombinant protein has a predicted molecular mass of approximately 17 kD. Recombinant human IL-17E forms a non-disulfide-linked homodimer (34 kD). The predicted N-terminal amino acid is Met.

    Purity    >98%, as determined by Coomassie stained SDS-PAGE.
    Formulation    Lyophilized
    Endotoxin Level    Less than 0.1 ng per µg of protein.
    Storage & Handling
    Unopened vial can be stored at -20°C or -70°C. For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1% BSA and store working aliquots at -20°C to -80°C. Avoid repeated freeze/thaw cycles.

    Activity
    Human IL-17E is able to induce IL-8 secretion in human PBMCs using a concentration range of 10 - 100 ng/ml. Note: Results will vary with PBMC donors.
    Application   Bioassay

    Antigen Details
    Structure  Cytokine
    Distribution   T cells, neurons
    Function
    Human IL-17E plays an important role in inflammatory responses, anti-tumor immunity, airway remodeling, and autoimmune diseases.

    Interaction
    Fibroblasts, endothelial cells, epithelial cells, keratinocytes, macrophages.
    Ligand/Receptor   IL-17RB
    Bioactivity   Human IL-17E induces IL-8 secretion in PBMCs.
    Biology Area
    Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Signal Transduction

    Molecular Family   Cytokines/Chemokines

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