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- 英文名：
BioLegend 537204 Biotin anti-human IFN-α2
- 供应商：
北京云肽生物科技有限公司
BioLegend 537204 Biotin anti-human IFN-α2
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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BioLegend 537204 Biotin anti-human IFN-α2
产品简介：
产品品牌：BioLegend
产品货号：537204
产品名称：BioLegend 537204 Biotin anti-human IFN-α2
产品规格：100 µg
产品说明：
Clone BL25372 (See other available formats)
Regulatory Status RUO
Other Names
IFN-alpha 2B, IFN-alphaA, IFNA2, IFNA2B, Interferon Alpha 2
Isotype Mouse IgG1
描述
干扰素分为I型、II型和III型。I型干扰素（IFN-α和IFN-β）在数量、分布和表达方面最丰富。此外，它们在哺乳动物中的结构和功能都高度保守。IFN-α2已被用于治疗癌症，如膀胱癌症、肝细胞癌和白血病。IFN-α2增强头颈部鳞状细胞癌（HNSCC）患者被抑制的免疫功能。IFN-α2通过IFN-γ依赖性和非依赖性机制启动T细胞和NK细胞介导的肿瘤细胞毒性。IFN-α2通过刺激穿孔素颗粒酶B系统（IFN-γ依赖性）增强被抑制的T细胞毒性。此外，IFN-α2诱导穿孔素颗粒酶B在NK细胞中的表达（NK介导的细胞毒性，IFN-γ无关）。在一项初步研究中，IFN-α2似乎是一种有效的免疫刺激剂，并影响舌鳞状细胞癌患者的临床结果。应用干扰素-α治疗慢性丙型肝炎；然而，IFN-α是相对不稳定的，需要频繁的胃肠外给药。聚乙二醇（PEG）-INF-α的聚乙二醇化降低了体外活性，但增加了IFN-α的稳定性和血浆半衰期；因此，PEG-IFN-α在CHC治疗中已取代IFN-α。
Interferons are divided into type I, II, and III. Type I IFNs (IFN-α and IFN-β) are most abundant in number, distribution, and expression. Also, they are highly conserved among mammals in both structure and function. IFN-α2 has been used in the treatment of cancer such as bladder cancer, hepatocellular carcinoma, and leukemia. IFN-α2 augments the suppressed immune functions in patients with head and neck squamous cell carcinoma (HNSCC). IFN-α2 initiated T and NK cell mediated cytotoxicity of tumor cells through IFNγ dependent and independent mechanisms. IFN-α2 enhances suppressed T cell cytotoxicity by stimulation of the perforin-granzyme B system (IFNγ dependent). Also, IFN-α2 induces the expression of perforin-granzyme B in NK cells (NK mediated cytotoxicity, IFNγ independent). In a preliminary study, IFN-α2 appears to be an effective immunostimulator and impacts the clinical outcome in tongue squamous cell carcinoma patients. IFN-α had been used in the treatment of chronic hepatitis C (CHC); nevertheless, IFN-α is relatively unstable and requires frequent parenteral administration. Pegylation of IFN-α, polyethylene glycol (PEG)-IFN-α, reduces in vitro activity but increase the stability and plasma half-life of IFN-α; therefore, PEG-IFN-α has replaced IFN-α in CHC treatment.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Recombinant protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application ELISA Detection - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA Detection applications, a concentration range of 0.05 - 0.4 µg/mL is recommended. To obtain a linear standard curve, serial dilutions of IFN-α2 recombinant protein ranging from 12.5 to 800 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
Distribution IFN-α is ubiquitously expressed.
Function
IFN-α stimulates cytotoxic T lymphocytes and natural killer cell function. IFN-α has immunomodulatory and antiviral properties. IFNα2a induces CXCL10 in human microvascular endothelial cells and pulmonary artery smooth muscle cells. It is induced by viral infection.
Interaction
A variety of cells express the IFNα receptor (IFNAR).
Ligand/Receptor
IFNAR complex has two components, IFNAR1 and IFNAR2.
Biology Area Immunology, Innate Immunity
Molecular Family Cytokines/Chemokines
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BioLegend 537204 Biotin anti-human IFN-α2
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