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BioLegend 369314 Brilliant Violet 421™ anti-human CD223 (LAG-3)
- 供应商：
北京云肽生物科技有限公司
BioLegend 369314 Brilliant Violet 421™ anti-human CD223 (LAG-3)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 369314 Brilliant Violet 421™ anti-human CD223 (LAG-3)
产品简介：
产品品牌：BioLegend
产品货号：369314
产品名称：BioLegend 369314 Brilliant Violet 421™ anti-human CD223 (LAG-3)
产品规格：100 tests
产品说明：
Clone 11C3C65 (See other available formats)
Regulatory Status RUO.
Other Names
CD223, LAG-3, LAG3, lymphocyte-activation gene-3
Isotype Mouse IgG1, κ
描述
CD223，也称为LAG-3，是一种70 kD I型跨膜糖蛋白，参与T细胞信号传导。与CD4类似，CD223结合MHC II类，但具有更高的亲和力。CD223负调节T细胞活化。它由活化的T细胞和自然杀伤细胞（NK）以及调节性T细胞表达。它在急性条件下在活化的T细胞表面短暂表达，但在耐受条件下保持高表达。CD223缺乏导致肿瘤生长减少。CD223和PD-1可以协同作用，逆转耗尽的表型，改善肿瘤排斥反应，控制病毒载量。
CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved in T-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223 negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells (NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated T-cells in acute conditions but high expression is maintained under tolerizing conditions. CD223 deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverse exhausted phenotypes, improve tumor rejection, and control viral load.
Product Details
Isotype Control
Brilliant Violet 421™ Mouse IgG1, κ Isotype Ctrl
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Human LAG-3 transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & HandlingThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Antigen Details
Structure
70 kD transmembrane glycoprotein, Ig superfamily, highly homologous to CD4.
Distribution
Activated T-cells and natural killer cells (NKs) and regulatory T cells.
Function Negatively regulates T-cell activation.
Ligand/Receptor Binds MHC class II molecules.
Cell Type Dendritic cells, NK cells, T cells, Tregs
Biology Area Immunology, Inhibitory Molecules
Molecular Family
CD Molecules, Immune Checkpoint Receptors
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BioLegend 369314 Brilliant Violet 421™ anti-human CD223 (LAG-3)
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