BioLegend 361029 Brilliant Vio

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BioLegend 361029 Brilliant Violet 785™ anti-human CD146
产品简介：
产品品牌：BioLegend
产品货号：361029
产品名称：BioLegend 361029 Brilliant Violet 785™ anti-human CD146
产品规格：361029

产品说明：
Clone  P1H12 (See other available formats)
Regulatory Status  RUO
Workshop  HCDM listed
Other Names  Muc-18, MCAM, Mel-CAM, S-endo
Isotype  Mouse IgG1, κ

描述
CD146 是一种 118 kD 的整合跨膜糖蛋白，也称为 MUC18、S-Endo、MCAM 和 Mel-CAM（黑色素瘤细胞粘附分子）。它属于免疫球蛋白超家族。CD146 在黑色素瘤细胞、上皮细胞、内皮细胞、成纤维细胞、活化 T 细胞、多能间充质基质细胞和活化的角质形成细胞上表达。CD146介导嗜异性细胞粘附并调节单核细胞跨内皮迁移。CD146的配体仍有待鉴定。
CD146 is a 118 kD integral transmembrane glycoprotein that is also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.

Product Details
Isotype Control
Brilliant Violet 785™ Mouse IgG1, κ Isotype Ctrl
Verified Reactivity   Human
Reported Reactivity   Mouse, Dog, Rabbit
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Cultured human umbilical cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).

Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 785™ under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Brilliant Violet 785™ excites at 405 nm and emits at 785 nm. The bandpass filter 780/60 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 785™ is a trademark of Sirigen Group Ltd.

Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser   Violet Laser (405 nm)

Application Notes
Additional reported applications (for the relevant formats of this clone) include: Western blotting3 and IHC1,5.

Clone P1H12 cross-reacts to Dog2, 5.

Antigen Details
Structure   118 kD integral glycoprotein, Ig superfamily
Distribution
Melanoma cells, epithelial cells, endothelial cells, activated T cells, multipotent mesenchymal stromal cells

Function   Adhesion, monocytes transendothelial migration
Cell Type
Endothelial cells, Epithelial cells, Mesenchymal cells, Mesenchymal Stem Cells, T cells

Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family   Adhesion Molecules, CD Molecules

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