产品说明: Clone 9C4 (See other available formats) Regulatory Status RUO Other Names Ep-CAM, tumor associated calcium signal transducer 1, epithelial cell surface antigen, epithelial glycoprotein 2, EGP2, adenocarcinoma associated antigen, TROP1 Isotype Mouse IgG2b, κ
描述 CD326也称为Ep-CAM,肿瘤相关钙信号换能器1,上皮细胞表面抗原,上皮糖蛋白2,EGP2,腺癌相关抗原和TROP1。CD326是一种I型跨膜蛋白,含有六个二硫键和一个甲状腺结构域。这种细胞表面糖基化的40 kD蛋白在骨髓,结肠,肺和大多数正常上皮细胞中高表达,并在胃肠道来源的癌中表达。最近,据报道CD326表达发生在红细胞生成的早期步骤中。CD326作为一种同型钙非依赖性细胞粘附分子,被认为通过诱导参与细胞代谢和增殖的基因的能力参与癌变。CD326抗原是治疗人类癌的免疫治疗靶点。 CD326 is also known as Ep-CAM, tumor associated calcium signal transducer 1, epithelial cell surface antigen, epithelial glycoprotein 2, EGP2, adenocarcinoma associated antigen, and TROP1. CD326 is a type I transmembrane protein containing six disulfide bridges and one THYRO domain. This cell surface glycosylated 40 kD protein is highly expressed in bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. Recently, it has been reported that CD326 expression occurs during the early steps of erythrogenesis. CD326 functions as a homotypic calcium-independent cell adhesion molecule and is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation. CD326 antigen is an immunotherapeutic target for the treatment of human carcinomas.
Product Details Isotype Control Alexa Fluor® 647 Mouse IgG2b, κ Isotype Ctrl Verified Reactivity Human Antibody Type Monoclonal Host Species Mouse Immunogen DU.4475 breast carcinoma Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) Preparation The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. Concentration Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.) Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested ICC - Verified SB - Reported in the literature, not verified in house
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses Excitation Laser Red Laser (633 nm) Application Notes Additional reported applications (for the revelant formats) include: immunofluorescence, immunohistochemistry3, and spatial biology (IBEX)4,5.
Additional Product Notes Iterative Bleaching Extended multi-pleXity (IBEX) is a fluorescent imaging technique capable of highly-multiplexed spatial analysis. The method relies on cyclical bleaching of panels of fluorescent antibodies in order to image and analyze many markers over multiple cycles of staining, imaging, and, bleaching. It is a community-developed open-access method developed by the Center for Advanced Tissue Imaging (CAT-I) in the National Institute of Allergy and Infectious Diseases (NIAID, NIH).
Antigen Details Structure Type I transmembrane protein, contains six disulfide bridges, one THYRO domain, approximate molecular weight 40 kD. Distribution Highly expressed in bone marrow, colon, lung, and most normal epithelial cells. Also highly expressed on carcinomas of gastrointestinal origin. Expressed during early erythrogenesis. Function Homotypic calcium-independent cell adhesion. CD326 is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation. Modification Glycosylated. Cell Type Embryonic Stem Cells, Epithelial cells Biology Area Cell Biology, Immunology, Stem Cells Molecular Family Adhesion Molecules, CD Molecules
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