产品说明: Clone DIH9 (See other available formats) Regulatory Status RUO Other Names T1/ST2, ST2L, IL-1R1, T1, DER4, IL1R1 Isotype Rat IgG2a, κ
描述 IL-33Rα,也称为ST2或IL-1RL1,是Toll/IL-1受体家族的成员。它结合IL-33并且在结构上类似于IL-1R1。该蛋白存在两种形式——一种是可溶性形式的ST2,另一种是膜锚定形式的ST2L。膜形式由Th2细胞和骨髓来源的肥大细胞表达,而可溶性形式由血清刺激的成纤维细胞表达。 用抗ST2抗体阻断已被证明可以减轻实验性关节炎和气道炎症。据报道,IL-33-ST2轴在哮喘、过敏和心脏病等一系列疾病中都很重要。 IL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist - a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts.
Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of diseases including asthma, allergies, and cardiac disease.
Product Details Isotype Control PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Rat Immunogen IL-33Rα-hFcγ1 fusion protein. Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Preparation The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions. Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is =1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
Excitation Laser Blue Laser (488 nm) Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Additional Product Notes BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.
Antigen Details Structure 63 kD, IL-1 receptor family member, single pass type I membrane protein Distribution Mast cells, Th2 cells, and fibroblasts
Function Following interaction with IL-33, it recruits MyD88, Irak1, Irak4 and Traf6 followed by phosphorylation of the MAP/ERK pathway. Interaction Interacts with MyD88, Irak1, Irak4 and Traf6 Ligand/Receptor IL-33 Cell Type Fibroblasts, Mast cells, Th2 Biology Area Immunology, Innate Immunity Molecular Family Cytokine/Chemokine Receptors
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