BioLegend 136512 PerCP/Cyanine5.5 anti-mouse CD93 (AA4.1, early B lineage) 产品简介: 产品品牌:BioLegend 产品货号:136512 产品名称:BioLegend 136512 PerCP/Cyanine5.5 anti-mouse CD93 (AA4.1, early B lineage) 产品规格:100 µg
产品说明: Clone AA4.1 (See other available formats) Regulatory Status RUO Other Names AA4.1, C1qRp, Early B lineage antigen Isotype Rat IgG2b, κ
描述 CD93是一种130-140kD的C型凝集素样I型跨膜蛋白,也称为补体组分1、q亚组分(C1qR1)、C1qRp集合蛋白受体(C1qRp)或AA4抗原。它是一种在未成熟B淋巴细胞、造血祖细胞和成人骨髓、胎儿肝脏、胚胎卵黄囊干细胞上表达的受体。脾脏未成熟/过渡期B细胞的CD93表达水平远低于骨髓。它在浆细胞分化过程中被重新诱导,并在维持浆细胞在骨髓小生境中发挥重要作用。未成熟的树突状细胞表达CD93,并在成熟时下调该分子,表明其在DC摄取颗粒中发挥作用。它也在单核细胞、巨噬细胞和内皮细胞上表达。来自CD93(-/-)小鼠的巨噬细胞在体内清除凋亡细胞方面存在显著的吞噬缺陷,表明CD93可能有助于体内清除垂死细胞。CD93与C1q的结合仍然存在争议。 CD93 is a 130-140kD C-type lectin like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen. It is a receptor expressed on immature B lymphocytes, hematopoietic progenitors and stem cells in adult bone marrow, fetal liver, embryonic yolk sac. CD93 expression level on splenic immature/transitional B cells is much lower than in bone marrow. It is reinduced during plasma cell differentiation and plays an important role in maintaining plasma cells in bone marrow niches. Immature dendritic cells express CD93 and down-regulate this molecule upon maturation, suggesting a role in uptake of particles by DC. It is also expressed on monocytes, macrophages, and endothelial cells. Macrophages from CD93 (-/-) mice had a significant phagocytic defect in the clearance of apoptotic cells in vivo, indicating CD93 may contribute to the in vivo clearance of dying cells. Binding of CD93 to C1q remains controversial.
Product Details Isotype Control PerCP/Cyanine5.5 Rat IgG2b, κ Isotype Ctrl Verified Reactivity Mouse Antibody Type Monoclonal Host Species Rat Immunogen Pre-B lymphoma 70Z/3 Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions. Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
Additional Product Notes BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.
Antigen Details Structure A 130-140 kD C-type lectin like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen.
Distribution Expressed during immature B lymphocytes, hematopoietic progenitors and stem cells in bone marrow, immature dendritic cells, monocytes, macrophages, and endothelial cells.
Function CD93 plays an important role in maintaining of plasma cells in bone marrow niches. It may play a role in uptake of particles by DC and the in vivo clearance of dying cells by macrophages.
Cell Type B cells, Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Monocytes Biology Area Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family CD Molecules
以下是BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 120801 Purified anti-mouse/human PNAd MECA-79 50 ug BioLegend 120802 Purified anti-mouse/human PNAd MECA-79 500 ug BioLegend 120803 Biotin anti-mouse/human PNAd MECA-79 50 ug BioLegend 120804 Biotin anti-mouse/human PNAd MECA-79 500 ug BioLegend 120808 Alexa Fluor® 647 anti-mouse/human PNAd MECA-79 100 ug BioLegend 120810 Spark YG™ 570 anti-mouse/human PNAd MECA-79 100 ug BioLegend 121010 FITC anti-human/mouse integrin β7 FIB27 100 ug BioLegend 121102 Purified anti-mouse CD127 (IL-7Rα) SB/199 500 ug BioLegend 121106 FITC anti-mouse CD127 (IL-7Rα) SB/199 500 ug BioLegend 121106 FITC anti-mouse CD127 (IL-7Rα) SB/199 500 ug BioLegend 121111 PE anti-mouse CD127 (IL-7Rα) SB/199 50 ug BioLegend 121112 PE anti-mouse CD127 (IL-7Rα) SB/199 200 ug BioLegend 121119 PE/Cyanine7 anti-mouse CD127 (IL-7Rα) SB/199 25 ug BioLegend 121121 APC anti-mouse CD127 (IL-7Rα) SB/199 25 ug BioLegend 121204 Biotin anti-mouse CD43 Activation-Associated Glycoform 1B11 200 ug BioLegend 121204 Biotin anti-mouse CD43 Activation-Associated Glycoform 1B11 200 ug BioLegend 121216 PE/Cyanine5 anti-mouse CD43 Activation-Associated Glycoform 1B11 100 ug BioLegend 121406 PE anti-mouse CD103 20000000 100 ug BioLegend 121408 Alexa Fluor® 488 anti-mouse CD103 20000000 100 ug BioLegend 121410 Alexa Fluor® 647 anti-mouse CD103 20000000 100 ug BioLegend 121413 APC anti-mouse CD103 20000000 25 ug BioLegend 121414 APC anti-mouse CD103 20000000 100 ug