Biotin-labeled ODN 1826

Nature：癌症疫苗新突破！调动 T 细胞与 NK 细胞的双重攻击，全面杀灭癌细胞

-巨噬细胞集落刺激因子（GM-CSF）和佐剂 CpG ODN 1826 都被整合到该疫苗设计中。 图片来源：Nature 对转移性肿瘤的疗效 后续的实验结果表明，MICB α3 域疫苗（MICB-vax）可诱导高滴度的抗体，同时还能诱导 CD4+ T 细胞的增殖和增强 CD8+ T 细胞对 MICB 的反应。在体内，MICB-vax 可明显抑制 MICB 的脱落，并大大增加了细胞表面密度 MICB 的水平以及抗肿瘤作用。 图片来源：Nature 为了评估 MICB-vax 诱导的免疫记忆，在初次

Chemistry of Minor Groove Binder–Oligonucleotide Conjugates

hybridization conditions to be used in DNA probe?based assays. MB?ODNs are especially useful in quantitative ?real?time? PCR assays since they bind efficiently during the high?temperature primer extension cycle. The synthesis and biophysical chemistry of MB?ODN

Oligodeoxynucleotide Containing S‐Functionalized 2′‐Deoxy‐6‐Thioguanosine: Facile Tools for Base‐Selective and Site‐Specific Internal Modification of

oligonucleotides with enzyme, photochemistry, or catalytic DNA. The functionality?transfer ODN (FT?ODN), which contains 2??deoxy?6?thioguanosine (6?thio?dG) functionalized with the 2?methyliden?1,3?diketone group, is hybridized with the target RNA to trigger