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- 2025年07月12日
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Anti-neuroinflammation agent 1
MCE 国际站：Anti-neuroinflammation agent 1
产品活性：Anti-neuroinflammation agent 1 是一种强效抗神经炎症剂，可调节 BV2 小胶质细胞从 M1 表型到 M2 表型的极化。
作用靶点：NOD-like Receptor (NLR) | Interleukin Related
In Vitro: Anti-neuroinflammation agent 1 (BMP 29) shows more potent anti-neuroinflammatory activity and no toxicity to BV2 microglia cells in vitro. Anti-neuroinflammation agent 1 significantly reduces the number of M1 phenotype of microglia cells, but significantly increases the number of M2 phenotype of microglia cells in lipopolysaccharide (LPS)-induced BV2 microglia cells. Anti-neuroinflammation agent 1 significantly reduces the secretion of inflammatory cytokines (IL-18, IL-1β, TNF-α), but increases the secretion of anti-inflammatory cytokines (IL-10) from LPS-induced BV2 microglia cells. Also, Anti-neuroinflammation agent 1 inhibits the NOD-like receptor NLRP3 inflammasome formation, and down-regulated the expression of M2 isoform of pyruvate kinase in LPS-induced BV2 microglia cells.
In Vivo: In mice, Anti-neuroinflammation agent 1 (BMP 29) reduces the neuroinflammation in cuprizone-induced inflammatory and demyelinating mice by reducing the expression of inducible nitric-oxide synthase, but increased the expression of CD206.
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文献和实验Intracranial Injection of LPS in Rat as Animal Model of Neuroinflammation
inflammation-inducing agent. This toxin is a potent inducer of inflammation and has different effects on cells of the immune system, as microglial cells. This chapter describes a protocol for the model of brain inflammation in rats based on the unilateral
AntibodyCytotoxic Agent Conjugates: Preparation and Characterization
cytotoxic agents that inhibit essential cellular targets such as microtubules or DNA. Antibody–cytotoxic agent conjugates (ACCs) against several types of cancer are currently in advanced stages of clinical trials and one, gemtuzumab ozogamicin (Mylotarg�
Anti-GFP/BrdU In Situ Immunostaining
Materials 24 well dishes Millicell 0.4 µm inserts (Millipore PICM01250) - coated with fibronectin Culture medium PBS Fixative: 4% paraformaldehyde in PBS (pH 7.6) Rabbit anti-GFP (Molecular Probes, A-11122) FITC-goat anti-rabbit
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