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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2911610-03-0
- 规格：
1 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥298.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥663.0 |
| 规格： | 10 mg | 产品价格： | ￥1071.0 |
| 规格： | 25 mg | 产品价格： | ￥1850.0 |
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Anti-inflammatory agent 51
CAS No. : 2911610-03-0
MCE 国际站：Anti-inflammatory agent 51
产品活性：Anti-inflammatory agent 51 (compound 11d) 是一种酰胺/磺酰胺衍生物，具有抗炎活性。Anti-inflammatory agent 51 抑制 NF-κB 激活，具有用于急性肺损伤和溃疡性结肠炎研究的潜力。
研究领域：NF-κB
作用靶点：NF-κB
In Vitro: Anti-inflammatory agent 51 (compound 11d) potently reduces the release of IL-6 ( IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM) , and decreased the mRNA level of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 into the nucleus.
In Vivo: Anti-inflammatory agent 51 (compound 11d) improved LPS-induced acute lung injury (ALI) and alleviated DSS-induced ulcerative colitis in mice.
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