- ￥750 - 22100
- 爱必信(absin)
- 上海
- abs172156
- 2025年07月13日
- SPR: 125nM-1.95nM
- Rat
- -
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
-
- 亚型：
-
- 形态：
液态
- 保存条件：
Store at 4℃ for one year.
- 克隆性：
R072
- 标记物：
-
- 适应物种：
-
- 保质期：
Store at 4℃ for one year.
- 抗原来源：
-
- 目录编号：
-
- 级别：
-
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 宿主：
Rat
- 应用范围：
SPR: 125nM-1.95nM
- 浓度：
-
- 靶点：
-
- 抗体英文名：
Rat anti-PD-L1 Recombinant Monoclonal Antibody,F(ab')₂ Fragment(R072)
- 抗体名：
Rat anti-PD-L1 Recombinant Monoclonal Antibody,F(ab')₂ Fragment(R072)
- 规格：
1mg/5mg/25mg/50mg
| 规格： | 1mg | 产品价格： | ￥750.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2250.0 |
| 规格： | 25mg | 产品价格： | ￥11250.0 |
| 规格： | 50mg | 产品价格： | ￥22100.0 |
| 概述 | |
| 宿主 | Rat |
| 反应种属 | Mouse |
| 应用 | SPR: 125nM-1.95nM |
| 性能 | |
| 形式 | Liquid |
| 纯化方法 | Protein G affinity column |
| 类型 | Monoclonal Antibody |
| 克隆号 | R072 |
| 储存/保存方法 | Store at 4℃ for one year. |
| 存储溶液 | PBS pH7.4 |
| 靶标 | |
| 背景说明 | Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate. |
| 细胞定位 | Membrane |
| UniProt | Q9EP73 |
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文献和实验Notes on Making Rat x Y3 Monoclonal Antibody Producing Hybridomas
7.16 anti-rat IgG2b). -------------------------------------------------------------------------------- 5) For full details see: Clark, M.R., & Waldmann, H. Production of murine monoclonal antibodies in Methods in Hematology 13:1-20 (1986
Protocol for anti-HA antibody Western Blotting
film for ~2 mins. Notes on the primary antibody: Source : Covance/Babco Description: Crude ascites fluid monoclonal anti-HA antibody (CATLN#135032002, 11mms-101R, 0.5 ml) Handling: Aliquoted into 10ul portions in -20℃ Internal notes: labelled anti
Protocol for anti-HA antibody Western Blotting
room. Expose film for ~2 mins. Notes on the primary antibody: Source - Covance/Babco Description: Crude ascites fluid monoclonal anti-HA antibody (CATLN#135032002, 11mms-101R, 0.5 ml) Handling: Aliquoted into 10ul portions in ―20c
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