人CLDN3重组蛋白(Clostridium perfrin

英文名称：

Recombinant Human Claudin-3 (CLDN3)-VLPs (Active)

品名简称：

Recombinant Human CLDN3 protein-VLPs (Active)

货号：

CSB-MP005505HU

规格:

20μg

价格：

3348

LC-MS/Western Blot：

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SDS-PAGE：

CSB-MP005505HU is detected by Mouse anti-6*His monoclonal antibody.

纯度：

The purity information is not available for VLPs proteins.

内毒素：

Less than 1.0 EU/μg as determined by LAL method.

生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN3 at 10 μg/mL can bind Anti-CLDN3 recombinant antibody (CSB-RA005505MA1HU)， the EC50 is 23.62-34.37 ng/mL. VLPs (CSB-MP3838) is negative control.

基因名：

CLDN3

Uniprot No.：

O15551

别名：

(Clostridium perfringens enterotoxin receptor 2)(CPE-R 2; CPE-receptor 2)(Rat ventral prostate.1 protein homolog)(hRVP1)

种属：

Homo sapiens (Human)

蛋白长度：

Full Length

来源：

Mammalian cell

分子量：

24.7 kDa

表达区域：

1-220aa

氨基酸序列：

MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV

蛋白标签：

C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)

产品提供形式：

Lyophilized powder

缓冲液：

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

储存条件：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.

保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

货期：

3-7 business days

注意事项：

The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).

功能1：

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

功能2：

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文献：

"Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis." Pan X.Y., Li X., Weng Z.P., Wang B. Fertil Steril 91:1692-1699(2009)

研究领域：

Cancer & Signal Transduction

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