In Vitro: Excisanin A (5-80 µM; 24, 48, 72 h) shows antiproliferative activity in a time and dose dependent manner in MDA-MB-231, SKBR3 cells. Excisanin A (10, 20, 40 µM; 24 h) inhibits cell migration, adhesion and invasion in MDA-MB-231, SKBR3 cells. Excisanin A (10, 20, 40 µM; 24 h) decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein in a dose dependent manner in MDA-MB-231 cells.