In Vitro: BT1718 (IC50=1 nM, 72 h) shows cytotoxicity in HT-1080 cells, measured in ATP endpoint assay.
In Vivo: BT1718 (10 mg/kg, i.v., tiw) shows rapid and complete tumour clearance in a cell-derived xenograft model in mice implanted with MT1-positive EBC-1 cells. BT1718 (10 mg/kg, i.v., qw or biw) leads to complete tumour clearance in a cell-derived xenograft model in mice implanted with MT1-positive HT-1080 cells.