高选择性抑制剂库

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Highly Selective Inhibitors Library

MCE 国际站：Highly Selective Inhibitors Library

According to reports, most known kinase inhibitors exert their effects through competitive binding in highly conserved ATP pockets. Although genetic techniques such as RNA interference can inactivate specific genes, most kinases are multi domain proteins, each of which has an independent function. Highly selective inhibitors have higher efficiency than non-selective inhibitors, and the selectivity to the target is at least 100 times higher. Therefore, ensuring the validation of targets with the most selective inhibitors is crucial for a more thorough understanding of the pharmacology of the kinase field. The Highly Selective Inhibitors Library contains 4458 compounds, covering multiple targets and subtypes, such as GPCR protein family, Ion channel, multiple kinases, etc. The Highly Selective Inhibitors Library is an effective tool for screening different phenotypes

Description & Advantages:

•    A unique collection of 4458 highly selective inhibitors covering more than 1000 targets and isoforms.

•   A useful tool for drug discovery.

•   Target diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.