CC214-1,1021920-32-0

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CC214-1

CAS No. : 1021920-32-0

MCE 国际站：CC214-1

产品活性：CC214-1 是一种潜在有效的 mTOR 抑制剂，可诱导自噬 (autophagy)，IC₅₀ 为 0.002 μM。 CC214-1 被证明可作为体外工具化合物用于探索 mTOR 激酶生物学。 CC214-1 可用于胶质母细胞瘤研究。

研究领域：PI3K/Akt/mTOR

作用靶点：mTOR

In Vitro: CC214-1 (0, 0.1, 1, 2, 5, 10 μM, 8 h; 2 μM, 24 h) synergize with rapamycin (HY-10219), inhibiting mTORC1 signaling and tumor cell proliferation.
CC214-1 (2 μM, 24 h) -mediated sensitivity to growth arrest in glioblastoma cells due to EGFRvIII expression and loss of PTEN.
CC214-1 (5 μM, 0-48 h) massively lipidates LC3B-I to LC3B-II subtype and induces autophagy in GBM39 cells.
CC214-1 has an IC₅₀ of mTOR is 0.002 μM.
CC214-1 (0-10 μM, 4days) is efficient in inhibiting T cell activation and the expression of T-cell activation markers.

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