E.coli-derived human CD20/MS4A1 recombinant protein (Position: M1-P297).
内容
500 ug/ml antibody with PBS ,0.02% NaN3 , 1 mg BSA and 50% glycerol.
纯化方式
protein G purified.
浓度
500 ug/ml
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
CD20, also known as MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. It is mapped to 11q12.2. This gene encodes a member of the membrane-spanning 4A gene family. The function of CD20 is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that CD20 acts as a calcium channel in the cell membrane. What’s more, this protein may be involved in the regulation of B-cell activation and proliferation.
研究类别
1. Cragg MS, Walshe CA, Ivanov AO, Glennie MJ (2005). "The biology of CD20 and its potential as a target for mAb therapy".?Curr. Dir. Autoimmun. Current Directions in Autoimmunity?8: 140–74. 2. Hardy, Richard (2008). "Chapter 7: B Lymphocyte Development and Biology". In Paul, William.Fundamental Immunology?(Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp.?237–269.3. Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA (January 2010).?"CD20 deficiency in humans results in impaired T cell-independent antibody responses".?J. Clin. Invest.?120?(1): 214–22.
[list_product_images]Figure 1. ICC analysis using anti- CD20/MS4A1 Antibody (M03780-4). was detected in immersion fixed human tonsil tissue. Cells were stained using the Dylight550-conjugated Anti- mouse IgG Secondary Antibody (red)(Catalog # BA1134) and counterstained with DAPI (blue).cy3-conjugated Anti- mouse IgG Secondary Antibody (red)(Catalog # BA1031).[/list_product_images]