A synthetic peptide corresponding to a sequence at the C-terminus of human MCM4(815-829aa TPALKYQQLFEDIRG), identical to the related rat and mouse sequences.
亚型:
Rabbit IgG
形态:
Lyophilized
保存条件:
12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
克隆性:
单克隆
适应物种:
Human,Mouse,Rat
抗原来源:
Rabbit
库存:
现货
供应商:
博士德生物
应用范围:
WB
浓度:
500ug/ml
规格:
50ul/100ul/150ul
规格:
50ul
产品价格:
¥860.0
规格:
100ul
产品价格:
¥1520.0
规格:
150ul
产品价格:
¥2280.0
产品概况
货号
BA3681-2
产品名称
ANTI-MCM4 Antibody
基因名
MCM4
抗体来源
Rabbit
克隆
Polyclonal
抗体亚型
Rabbit IgG
免疫原
A synthetic peptide corresponding to a sequence at the C-terminus of human MCM4(815-829aa TPALKYQQLFEDIRG), identical to the related rat and mouse sequences.
内容
500ug/ml antibody with PBS ,0.02% NaN3 , 1mg BSA
纯化方式
Immunogen affinity purified.
浓度
500ug/ml
产品形态
Lyophilized
保存条件
12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料
MCM4(MINICHROMOSOME MAINTENANCE, S. CEREVISIAE, HOMOLOG OF, 4), also called CDC21, S. POMBE, HOMOLOG OF, is a protein that in humans is encoded by the MCM4 gene. MCM4 is one of the highly conserved mini-chromosome maintenance proteins(MCM) that are essential for the initiation of eukaryotic genome replication. The MCM4 gene is mapped to 8q11.21. The 864-amino acid MCM4 protein has an observed molecular mass of 97 kD by SDS-PAGE, which is similar to its calculated molecular mass of 96.6 kD. Western blot analysis with and without phosphatase treatment suggested that MCM4 is highly phosphorylated in mitotic cells. In the absence of DDK, CDK phosphorylation at the distal part of the Mcm4 NSD becomes crucial.MCM4 encodes a subunit of the MCM2-7 complex(also known as MCM2-MCM7), the replication licensing factor and presumptive replicative helicase.
研究类别
1. Connelly, M. A., Zhang, H., Kieleczawa, J., Anderson, C. W. The promoters for human DNA-PK(cs) (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. Genomics 47: 71-83, 1998.2. Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., Almouzni, G. Regulation of replication fork progression through histone supply and demand. Science 318: 1928-1931, 2007.3. Hu B, Burkhart R, Schulte D et al (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins". Nucleic Acids Res. 21 (23): 5289–93.
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。