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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant mouse IL-12 p70
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4℃. For long-term storage, aliquot and store at -20℃ or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Mouse
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Mouse
- 目录编号:
GTX02953
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Rat
- 应用范围:
ELISA, Sandwich ELISA
- 浓度:
1 mg/ml(Please refer to the vial label for the specific concentration.)
- 靶点:
In combination with different detection antibodies, it is able to recognize p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40 + p35), and IL-23 heterodimer (p40 + p19).
- 抗体英文名:
IL12B / IL12 p40 antibody [C15.6]
- 抗体名:
IL12B / IL12 p40 抗体 [C15.6]
- 规格:
250 μg
Sandwich ELISA analysis of mouse IL-12/-23 (p40) protein using GTX02953 IL12B / IL12 p40 antibody [C15.6] as coating antibody and GTX02954-02 IL12B / IL12 p40 antibody [C17.8] (Biotin) as detecting antibody.
Substrate : pNPP
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文献和实验1, CALM2, CALM3, CAMK2B, CAMK4, CNR1, ITK, MAP2K7, NCK2, PAK1, PPIA, PPP3CB, PPP3CC, PPP3R1, TRPV6, VAV1, VAV2, VAV3. Ligands: CCL2, CSF2, CSF3, IFNA1, IFNB1, IFNG, IL1A, IL1B, IL2, IL3, IL4, IL6, IL8, IL10, IL12A, IL12B, IL13, IRF1, LTA, TGFB1, TNF
陈有海团队 Nature Cancer 报道髓系细胞检查点,会是癌症免疫治疗下一个热点吗?
肿瘤基因(如 Il1b、Tnfa 和 Il12p40)的表达上调。 图片来源:Nature Cancer c-Rel 增强小体调控 MDSCs 基因的表达c-Rel 作为转录因子可通过直接结合其靶基因的调控区域来发挥功能。所以作者进行了启动子激活、染色质免疫沉淀(ChIP)和 Re-ChIP 分析。结果发现,在骨髓来源的 MDSCs 中,c-Rel 可结合 Cebpb 和 Arg1 基因启动子。Re-ChIP 分析显示,转录因子 C/EBPβ、pSTAT3 可以和 c-Rel 结合到相同的启动子元件上,表明形成
though that some antibodies will only recognize a protein in its native, non-denatured form and will not recognize a protein that has been extracted with a denaturing detergent (SDS, deoxycholate, and somewhat less denaturing, Triton X-100 and NP-40). The main
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