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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2766570-23-2
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2088.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥4950.0 |
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Nrf2 activator-3
CAS No. : 2766570-23-2
MCE 国际站：Nrf2 activator-3
产品活性：Nrf2 activator-3 是一种有效的 Nrf2 激活剂。Nrf2 activator-3 用于脑缺血损伤研究。
研究领域：NF-κB
作用靶点：Keap1-Nrf2
In Vitro: Nrf2 activator-3 (compound 24) (1 μM, 5 μM, and 10 μM) is against SNP (400 μM)-induced cell death with IC50 values of 76.86±3.54 μM, 101.59±3.34 μM, and 105.1±1.84 μM at 1 μM, 5 μM, and 10 μM, respectively in PC12 cells。
Nrf2 activator-3 (1-200 μM) is against PC12 and hacat cell with IC50 values of 262.70±1.98 μM and 126.70±10.39 μM, respctively。
In Vivo: In the acute toxicity study, Nrf2 activator-3 (compound 24) shows toxicity to the experimental mice at 1000 mg/kg, the LD50 of intraperitoneal injection is 789 mg/kg, and the 95% confidence interval was 550-1000 mg/kg in balb/c mice.
.In in vivo pharmacokinetic properties study, Nrf2 activator-3 (5 mg/kg; Intraperitoneal injection) shows that plasma reached a maximum (323.06 ng/mL) at 2 h. the Tmax, Cmax, AUC0-inf, F% and T1/2 values are 2 hour, 323.06 ng/mL, 2929.88 ng/mL*h, 28%, 12.75 hours respctively.
.Nrf2 activator-3 (5 mg/kg; .i.v.) shows Tmax, Cmax, AUC0-inf, and T1/2 values are 0.08 hours, 6911.14 ng/mL, 10182.73 ng/mL*h, and 8.26 hours respctively.
.Nrf2 activator-3 (3 mg/kg; 10 mg/kg;30 mg/kg) reduces the cerebral infarction volume and leads to decreased neurological deficits in MCAO rats.
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文献和实验Role of Nrf2-Dependent ARE-Driven Antioxidant Pathway in Neuroprotection
The promoter regions of many detoxification enzymes contain a cis -acting enhancer known as the antioxidant response element (ARE). NF-E2-related factor 2 (Nrf2) is considered as one of the major transcription factors
Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals
acting by activating the transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2 or NFE2L2), a basic-region leucine zipper (bZIP) transcription factor that regulates the expression of many phase II detoxifying/antioxidant enzymes
Examining the Endogenous Antioxidant Response Through Immunofluorescent Analysis of Nrf2 in Tissue
conserved mechanism for preventing oxidative stress. NF-E2 (nuclear factor (erythroid-derived 2))-related factor-2 (Nrf2) is the primary regulator of this endogenous antioxidant response. Many diseases that plague human society, ranging from various cancers
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