TrkB-IN-1,1609067-49-3

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TrkB-IN-1

CAS No. : 1609067-49-3

MCE 国际站：TrkB-IN-1

产品活性：TrkB-IN-1 是一种有效的具有口服活性的 TrkB 激动剂，具有良好的药代特性。TrkB-IN-1 逆转 AD 小鼠模型中的认知缺陷，可用于阿尔茨海默病研究。

研究领域：Neuronal Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：Trk Receptor

In Vivo: TrkB-IN-1 (oral gavage; 7.25 mg/kg, 21.8 mg/kg, 43.6 mg/kg; 3 month) activates TrkB signaling cascade in the hippocampus of 5XFAD mice in a dose-dependent manner in 5XFAD mice, the ratio of p-TrkB/TrkB, p-Akt/Akt and p-ERK/ERK is also increased.
TrkB-IN-1 (oral gavage; 7.25 mg/kg, 21.8 mg/kg, 43.6 mg/kg; 5 days) alleviates Aβ deposition and rescues memory deficits in 5XFAD mice.
TrkB-IN-1 (oral gavage; 36 mg/kg) exhibits ∼10.5% oral bioavailability with a C_max of 129 ng/mL, T_max of 0.5 h, and T_1/2 for oral administration of 3.66 h.

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