In Vitro: AMPA receptor modulator-4 (compound 15e) has pEC50 of 5.66 on the calcium influx induced by 1 mM Glutamate on HEK293 cells stably expressing the GluA2(Q) subunit. AMPA receptor modulator-4 has EC2x=2.1 μM (FlipR)-1.5 μM (FDSS) .
In Vivo: AMPA receptor modulator-4 (compound 15e; 10 and 30 mg/kg; IP; once) increases the duration of the LTP at a dose of 10 mg/kg in rats. AMPA receptor modulator-4 (1 and 3 mg/kg; po) 1 h before the three sessions significantly increases the cognition performance of CD1 mice. AMPA receptor modulator-4 (0.03, 0.1 and 0.3 mg/kg; ip) improves the performance of spontaneous alternation and improves working memory performance in C57BI/6 mice. AMPA receptor modulator-4 (30, 100 mg/kg; po; once) has non-pro-convulsant effect in NMRI mice.