In Vivo: m-CPBG hydrochloride (80 and 160 nM) significantly reduces water intake elicited by an acute salt load. m-CPBG hydrochloride (third ventricle injection; 160 nM) significantly inhibits water intake in hypovolemic animals. m-CPBG hydrochloride (third ventricle injection; 320 nM) decreases water intake in water-deprived rats. m-CPBG hydrochloride (central administration) inhibits water intake induced by pharmacological activation of central cholinergic and angiotensinergic pathways.