FAK-IN-9,2911655-93-9

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FAK-IN-9

CAS No. : 2911655-93-9

MCE 国际站：FAK-IN-9

产品活性：FAK-IN-9 (Compound 8f) 是一种有效的和具有口服活性的 FAK 抑制剂，其 IC₅₀ 为 27.44 nM。FAK-IN-9 诱导三阴性乳腺癌 (TNBC) 细胞凋亡(apoptosis)。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FAK

In Vitro: FAK-IN-9 (Compound 8f; 72 h) shows antiproliferative activity with IC₅₀s of 0.167±0.025, 0.126±0.012 and 0.159±0.017 μM against MDA-MB-157, MDA-MB-231 and MDA-MB-453 cells, respectively.
FAK-IN-9 (1-4 μM; 72 h) leads to relatively high levels of NO production in a dose-dependent manner in MDA-MB-231 cells.
FAK-IN-9 (1-4 μM; 48 h) inhibits invasion and migration of MDA-MB-231 cells.
FAK-IN-9 (1-4 μM; 72 h) efficiently blocks FAK mediated-signaling pathways.
FAK-IN-9 (4 μM; 72 h) inhibits the formation of focal adhesions (FAs) and stress fibers (SFs) in MDA-MB-231 cells.
FAK-IN-9 (1-4 μM; 72 h) induces MDA-MB-231 cell apoptosis.

In Vivo: FAK-IN-9 (Compound 8f; 15 or 30 mg/kg; oral; once daily for 30 days) inhibits MDA-MB-231 lung metastasis in mice.

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