IWP-2 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.
产品信息: 应用: FA 同义词: CHEMBL1257064, F0579-0037 配方:Crystalline solid 化学名称:N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide 分子式:C22H18N4O2S3 分子量:466.6 CAS号:686770-61-6 纯度:≥95% 储存条件:产品应保持在-20°C。 参考: Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107.
Loh, Y. N., Hedditch, E. L., Baker, L. A., Jary, E., Ward, R. L., & Ford, C. E. (2013). The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC cancer, 13(1), 174.
Mo, M. L., Li, M. R., Chen, Z., Liu, X. W., Sheng, Q., & Zhou, H. M. (2013). Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncology letters,5(5), 1719-1723.