9-cis-Retinoic acid is a potent activator of all isoforms of retinoic acid receptor and the retinoid X receptor, which act as transcription factors that regulate the growth and differentiation of normal and malignant cells.. It is reported to promote oligodendrocyte precursor cell differentiation and myelination and to also inhibit the synthesis of fatty acids and sterols in hepatocytes.
产品信息: 应用: FA 同义词: Alitretinoin, 9-cis-Tretinoin, Panretin 配方:Crystalline solid 化学名称:(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid 分子式:C20H28O2 分子量:300.4 CAS号:5300-03-8 纯度:≥95% 储存条件:产品应保持在-20°C。 参考: Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell, 68(2), 397-406.
Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., ... & Grippo, J. F. (1992). 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα.
MacDonald, P. N., Dowd, D. R., Nakajima, S., Galligan, M. A., Reeder, M. C., Haussler, C. A., ... & Haussler, M. R. (1993). Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1, 25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene. Molecular and cellular biology, 13(9), 5907-5917.