- 询价
- SCIENCELL
- 美国
- 4320
- 2025年11月24日
企业认证
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Human Urothelial Cells
- 库存：
999
- 品系：
原代细胞
- 组织来源：
人
- 物种来源：
人
- 器官来源：
膀胱
- 运输方式：
干冰
- 规格：
5 x 10^5 cells/vial
人尿道上皮细胞排列在膀胱表面，它是由高可塑性和具有多种功能特殊类型的细胞组成。它们是膀胱防御系统的第一层，做为与病原体的接触面，它们具有多种防御机制来阻止病原体粘着，保持泌尿器溶解物的不渗透性。膀胱上皮细胞表达雌激素α、β受体，上皮生长因子受体和纤维母细胞生长因子受体，在损伤和感染时，这些受体对膀胱上皮细胞起着重要作用。它们还能释放许多细胞因子、免疫系统介质，这些新被认知的具有免疫调节潜在能力的尿道上皮细胞保证了最近两项发展的进一步研究：1)在实验室中培养正常膀胱上皮细胞的能力，2)免疫调节信号系统如何通过信号转导使尿道上皮细胞产生生物学功能。 人尿道上皮细胞(HUC)提取于人膀胱组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对Cytokeratin-18, -19 和Vimentin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增 推荐培养基: 尿道上皮细胞培养基(UCM, Cat. No. 4321) 产品使用说明：仅供科研研究使用
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验1. Ting, K., Aitken, K.J., Penna, F., Samiei, A.N., Sidler, M., Jiang, J.X., Ibrahim, F., Tolg, C., Delgado-Olguin, P., Rosenblum, N. & Bagli, D.J. (2016) Uropathogenic E.coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2) PLoS One. volume 11
2. Tylden, G.D., Hirsch, H.H. & Rinaldo, C.H. (2015) Brincidofovir (CMX001) Inhibits BK Polyomavirus Replication in Primary Human Urothelial Cells Antimicrob Agents Chemother. 59
3. Steins, A., Dik, P., M�ller, W.H., Vervoort, S.J., Reimers, K., Kuhbier, J.W., Vogt, P.M., van Apeldoorn, A.A., Coffer, P.J. & Schepers, K. (2015) In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction PLoS One. 10
4. Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19
5. Li, C.F., Wu, W.J., Wu, W.R., Liao, Y.J., Chen, L.R., Huang, C.N., Li, C.C., Li, W.M., Huang, H.Y., Chen, Y.L., Liang, S.S., Chow, N.H. & Shiue, Y.L. (2015) The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma Oncotarget. 6
6. Lee, M.S., Kim, J.H., Lee, J.S., Yun, S.J., Kim, W.J., Ahn, H. & Park, J. (2015) Prognostic Significance of CREB-Binding Protein and CD81 Expression in Primary High Grade Non-Muscle Invasive Bladder Cancer: Identification of Novel Biomarkers for Bladder Cancer Using Antibody Microarray PLoS One. 10
7. Lu C, Lin M, Chen S, Shen C, Chen L, Hsieh H, Chan MWY, Hsu C. (2013) "The investigation of a traditional Chinese medicine, Guizhi Fuling Wan (GFW) as an intravesical therapeutic agent for urothelial carcinoma of the bladder." BMC Complement Altern Med. 13: 44.
8. Marentette JO, Hauser PJ, Hurst RE, Klumpp DJ, Rickard A, McHowat J. (2013) "Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase." PLoS One. 8: e69948.
9. Noguchi S, Yamada N, Kumazaki M, Yasui Y, Iwasaki J, Naito S, Akao Y. (2013) "socs7, a target gene of microRNA-145, regulates interferon-? induction through STAT3 nuclear translocation in bladder cancer cells." Cell Death Dis. 4: e482.
10. Lee WY, Savage JR, Zhang J, Jia W, Oottamasathien S, Prestwich GD. (2013) "Prevention of Anti-microbial Peptide LL-37-Induced Apoptosis and ATP Release in the Urinary Bladder by a Modified Glycosaminoglycan." PloS one. 8: e77854.
11. Tsang M, Chun YW, Im YM, Khang D, Webster TJ. (2011) "Effects of increasing carbon nanofiber density in polyurethane composites for inhibiting bladder cancer cell functions." Tissue Eng Part A. 17: 1879-89.
12. Bhattacharya A, Tang L, Li Y, Geng F, Paonessa JD, Chen SC, Wong MK, Zhang Y. (2010) "Inhibition of bladder cancer development by allyl isothiocyanate."Carcinogenesis. 31: 281-6.
13. Koizumi T, Nakatsuji H, Fukawa T, Avirmed S, Fukumori T, Takahashi M, Kanayama H. (2010) "The role of actinin-4 in bladder cancer invasion." Urology. 75: 357-64.
14. Stone R 2nd, Sabichi AL, Gill J, Lee IL, Adegboyega P, Dai MS, Loganantharaj R, Trutschl M, Cvek U, Clifford JL. (2010) "Identification of genes correlated with early-stage bladder cancer progression." Cancer Prev Res (Phila). 3: 776-86.
15. Chun YW, Khang D, Haberstroh KM, Webster TJ. (2009) "The role of polymer nanosurface roughness and submicron pores in improving bladder urothelial cell density and inhibiting calcium oxalate stone formation." Nanotechnology. 20: 085104.
