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- 2025年07月14日
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Anti-MRSA agent 7
MCE 国际站：Anti-MRSA agent 7
产品活性：Anti-MRSA agent 7 (Compound 12) 是一种有效的抗菌 (antibacterial) 剂。Anti-MRSA agent 7 抑制 S. aureus DNA gyrase、E. coli DNA gyrase、S. aureus topo IV 和 E. coli topo IV 的 IC50 分别为 0.185、0.365、0.341 和 0.059 μM。
研究领域：Anti-infection | Cell Cycle/DNA Damage
作用靶点：Bacterial | DNA/RNA Synthesis | Topoisomerase
In Vitro: Anti-MRSA agent 7 (Compound 12) shows a dose-dependent killing efficacy achieving bactericidal effect against planktonic methicillin-resistant S. aureus (ATCC 43300) at 8 × MIC after 8 h of treatment, after which re-growth occurs.
Antimicrobial activity of Anti-MRSA agent 7 (Compound 12) against a panel of Gram-positive and Gram-negative bacterial pathogens
| Strain | S. aureus (ATCC 29213) | MRSAQA-12.1 | E. coli N43 (CGSC# 5583) | MRSA QA-11.7 | MRSA QA-11.2 | E. faecalis DRK 057 | E. coli (ATCC 25922) |
| MIC (μM) | 0.03 | 0.03 | 0.06 | 0.06 | 0.124 | 4.07 | 252 |
| Strain | E. coli D22 | A. baumannii | E. coli ESBL QA:11.3 | K. pneumoniae | S. alachua RDK 030c | P. aeruginosa RDK 184 | |
| MIC (μM) | 252 | 252 | >252 | >252 | >252 | >252 |
In Vivo: Anti-MRSA agent 7 (Compound 12; 20 and 40 mg/kg; i.p.; QID for 1 day) demonstrates high in vivo efficacy in MRSA neutropenic mouse thigh infection model.
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The Design, Production, and Validation of an Anti-HIV Type 1 Ribozyme
The development of acquired immunodeficiency syndrome (AIDS) generally takes of the order of ten years with no effective therapy currently available (1 ,2 ). HIV, the causative agent, exhibits tropism for CD4+ T-lymphocytes, the primary
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