SB-435495 ditartrate,304694-43

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

SB-435495 ditartrate

CAS No. : 304694-43-7

MCE 国际站：SB-435495 ditartrate

产品活性：SB-435495 ditartrate 是一种有效的、选择性的、可逆的、非共价的、具有口服活性的 Lp-PLA₂ 抑制剂，IC₅₀ 为 0.06 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: SB-435495 ditartrate inhibits CYP450 3A4 with an IC₅₀ of 10 μM and the black membrane permeability is 0.017 cm/h.
SB-435495 (5 μM; 24 h) ditartrate significantly inhibits the expression of Lp-PLA₂ protein, while increases the expression levels of AMPKα and phosphorylated-AMPKα (T172) in oxLDL-exposed HUVECs.
SB-435495 (5 μM; 24-72 h) ditartrate significantly increases cell viability and NO expression, significantly decreases ET-1 expression in the oxLDL-exposed HUVECs.

In Vivo: SB-435495 (10 mg/kg; p.o.; once) ditartrate inhibits plasma Lp-PLA₂ in the WHHL rabbit.
SB-435495 (10 mg/kg; i.p.; daily for 28 days) ditartrate effectively suppresses blood–retinal barrier (BRB) breakdown in Streptozotocin (HY-13753)-diabetic Brown Norway rats.

相关产品：GW4869  |  Neomycin sulfate  |  U-73122  |  BAPTA  |  Compound 48/80 trihydrochloride  |  Omeprazole  |  D609  |  Darapladib  |  ML348  |  m-3M3FBS  |  ML349  |  Varespladib  |  N-(p-amylcinnamoyl) Anthranilic Acid  |  Tris(2,4-di-tert-butylphenyl)phosphate  |  MAFP  |  Tanshinone I  |  Lansoprazole  |  FIPI  |  CAY10650  |  U-73343  |  DPTIP  |  3-Nitrocoumarin  |  AACOCF3  |  LEI-401  |  Bromoenol lactone  |  Cambinol  |  Melittin TFA  |  AA26-9  |  Manumycin A

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds