Anti-inflammatory agent 36,229

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Anti-inflammatory agent 36

CAS No. : 2293951-01-4

MCE 国际站：Anti-inflammatory agent 36

产品活性：Anti-inflammatory agent 36 是一种抗炎剂。Anti-inflammatory agent 36 抑制 LPS 诱导的巨噬细胞活化。

研究领域：Others

作用靶点：Others

In Vitro: Anti-inflammatory agent 36 (Compound 5a28) (2.5-20 μM) inhibits LPS-induced release of TNF-α and IL-6 in active RAW 264.7 mouse macrophages, with IC₅₀s of 3.69 and 3.68 µM for TNF-α and IL-6.
Anti-inflammatory agent 36 (10 μM, 0.5 h) inhibits LPS-induced P-P38 and P-ERK in RAW 264.7 mouse macrophages.
Anti-inflammatory agent 36 (10 μM, 0.5 h) inhibits LPS-induced the transcription of TNF-α, IL-6, IL-1β, ICAM-1 and VCAM-1.

In Vivo: Anti-inflammatory agent 36 (Compound 5a28) (10 mg/kg, i.p.) inhibits inflammation in acute lung injury mouse model.

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