ORC-13661,1979935-34-6

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ORC-13661 hydrochloride

CAS No. : 1589571-77-6

MCE 国际站：ORC-13661 hydrochloride

产品活性：ORC-13661 hydrochloride 是一种毛细胞保护剂。ORC-13661 hydrochloride 保护感觉毛细胞免受氨基糖苷类和顺铂 (HY-17394) 的耳毒性。ORC-13661 hydrochloride 是一种可逆的机电传感器 (MET) 通道渗透阻滞剂。

研究领域：Others

作用靶点：Others

In Vitro: ORC-13661 (0.10-8.3 μM; wild type *AB Zebrafish hair cells) hydrochloride protects zebrafish hair cells from multiple aminoglycosides (AGs).
ORC-13661 (0.10-20 μM) hydrochloride protects zebrafish lateral line hair cells and mammalian hair cells from Cisplatin (HY-17394).
ORC-13661 (0.3 and 3 μM) hydrochloride is a reversible blocker of the MET channel of auditory hair cells. ORC-13661 hydrochloride blocks OHC MET currents. ORC-13661 hydrochloride MET channel block is voltage dependent and permeant.

In Vivo: ORC-13661 (0.2-5 mg/kg; p.o.; daily, for 10 d) hydrochloride protects hearing from amikacin in rats in a dose-dependent manner.

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