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CAS No. : 507453-82-9
MCE 国际站:Mirococept
产品活性:Mirococept (APT070) 是一种抗体,靶向补体系统 (complement system) 的 C3b/C4b,也是一种膜定位的 C3 转化酶抑制剂。Mirococept 减少 C 肽和促炎细胞因子的释放,并减少炎症细胞的浸润。Mirococept 减少胰岛内炎症,有利于胰岛移植。Mirococept 还抑制增加的肠和肺血管通透性以减少中性粒细胞流入。
研究领域:Immunology/Inflammation
作用靶点:Complement System
In Vitro: Mirococept (0.4-1.6 μM; 1 h) binds to islets, without inhibiting insulin secretory responses to glucose, nor to the receptor-mediated agonist, Carbachol, at 0.4 μM.
Mirococept (0.4 μM; 1 h) prevents the production of activated complement in vitro, and diminishes deposition of C4d (complement activation indicator) and C5b-9 (which causes cell lysis) in islets.
In Vivo: Mirococep-treated islets transplants into diabetic humanized NSG mice, reduces human islet destruction, and suppresses cytokine production at early stage.
Mirococept (1-10 mg/kg; i.v.; single dose) dose-dependently improves the in the mild reperfusion injury model in rats. Mirococept markedly suppresses the increase in vascular permeability and neutrophil recruitment in mouse ischaemia and reperfusion injury (I/RI) model.
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