FPR-A14,329691-12-5

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FPR-A14

CAS No. : 329691-12-5

MCE 国际站：FPR-A14

产品活性：FPR-A14 是一种有效的甲酰肽受体 (FPR) 激动剂。FPR-A14 是中性粒细胞 Ca²⁺ 动员和趋化作用的有效激活剂，EC₅₀ 分别为 630 nM 和 42 nM。FPR-A14 诱导细胞分化。

研究领域：GPCR/G Protein

作用靶点：Formyl Peptide Receptor (FPR)

In Vitro: FPR-A14 (compound 14) activates Ca²⁺ release with an EC₅₀ of 630 nM in human neutrophils. FPR-A14 is a neutrophil chemoattractant and dose-dependently induces neutrophil migration with an EC₅₀ value of 42 nM.
FPR-A14 (1-10 μM; 48h) elicites a significant increase in % cell differentiation versus controls at concentrations of 4μM (32.0%), 6μM (64.9%), 8μM (89.1%) and 10μM (93.3%) in mouse neuroblastoma N2a cells. FPRa14 (100μM) produces similar effects in IMR-32 and SH-SY5Y cells.

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