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- 2025年12月05日
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1403.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥460.0 |
| 规格： | 5 mg | 产品价格： | ￥1400.0 |
| 规格： | 10 mg | 产品价格： | ￥2450.0 |
| 规格： | 25 mg | 产品价格： | ￥4100.0 |
| 规格： | 50 mg | 产品价格： | ￥5763.0 |
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AD57
CAS No. : 1093380-42-7
MCE 国际站：AD57
产品活性：AD57 是一种具有口服活性的多种激酶抑制剂，抑制 RET、BRAF、S6K 和 Src 活性，但对 mTOR 的活性明显减弱。
研究领域：Protein Tyrosine Kinase/RTK | MAPK/ERK Pathway
作用靶点：RET | Raf | Ribosomal S6 Kinase (RSK) | Src
In Vitro: AD57 (0.2 nM) significantly inhibits the ptc > dRetMEN2B lethality in the larva of Drosophila.
AD57 (0.1 nM) enhances survival of ptc > dRetMEN2B by reducing erk gene dosage in Drosophila.
In Vivo: AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RETMEN2 models.
AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model.
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