In Vitro: NAMPT activator-3 (compound 72; 0.1, 0.3, 1, 3, 10 μM; 72 hours) exertes no side effect on the cell viability including osteosarcoma cells (U2OS), glioblastoma cells (T98G), neuroblastoma cells (SH-SY5Y) and liver carcinoma cells (HepG2).
In Vivo: NAMPT activator-3 (compound 72) protects peripheral sensory neurons from Taxol (HY-B0015)-induced damage by enhancing NAD production. Pharmacokinetic Parameters of NAMPT activator-3 in mice.