Temocaprilat,110221-53-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Temocaprilat

CAS No. : 110221-53-9

MCE 国际站：Temocaprilat

产品活性：Temocaprilat (Temocapril diacid) 是一种血管紧张素转换酶抑制剂 (Angiotensin-converting Enzyme，ACE)。Temocaprilat 缓解了高糖介导的主动脉内皮细胞增殖的抑制作用。Temocaprilat 在高血压和血管炎症中有潜在应用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Angiotensin-converting Enzyme (ACE)

In Vitro: Temocaprilat (1, 10, 100 and 1000 nM; 72 h) relieves high glucose (22.2 mM) mediated inhibition of human aortic endothelial cells (HAECs) proliferation with dose-dependent manner. Temocaprilat inhibits oxidative stress induced by high glucose in HAECs.
Temocaprilat (1 µM; 10 min) increases protein kinase C (PKC) activity in HAECs.
Temocaprilat (0.1 µM) inhibits IL-1β induced IL-6 expression by reducing the stability of IL-6 mRNA.

In Vivo: Temocaprilat (1 mg/kg/d; i.v.; 4 weeks) significantly reduces systolic blood pressure with time-dependent manner in spontaneously hypertensive (SHR) rats. Temocaprilat improves myocardial fibrosis and oxidative stress in Wistar-Kyoto (WKY) rats and SHR rats.

相关产品：Ursodeoxycholic acid  |  Captopril  |  Talfirastide  |  MLN-4760  |  Enalapril maleate  |  (Z)-Guggulsterone  |  Diminazene aceturate  |  Ramipril  |  Lisinopril dihydrate  |  BMS-265246  |  Sinapinic acid  |  Peimisine  |  Alamandine  |  Omapatrilat  |  Perindopril erbumine  |  Fosinopril sodium  |  Resorcinolnaphthalein  |  Benazepril hydrochloride  |  Enalaprilat dihydrate  |  Temocapril hydrochloride  |  Phosphoramidon Disodium  |  Plantainoside D  |  Deserpidine  |  DX600  |  Trandolapril  |  Mca-Ala-Pro-Lys(Dnp)-OH  |  Vicenin 2  |  Abz-FR-K(Dnp)-P-OH  |  H-Ile-Pro-Pro-OH hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds