INCB3619,791826-72-7

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INCB3619

CAS No. : 791826-72-7

MCE 国际站：INCB3619

产品活性：INCB3619 是一种选择性的，具有口服活性的 ADAM 抑制剂，作用于 ADAM10 和 ADAM17 的 IC₅₀ 值分别是 22 nM和 14 nM。INCB3619 具有抗肿瘤活性。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：MMP  |  Apoptosis

In Vitro: INCB3619 (0-10 μM, 96 h) can inhibit heregulin-dependent HER3-Akt pathway, but not ERK activity in A549 cells, and induce apoptosis in A549 cells.
INCB3619 (0-10 μM, 72 h) can inhibit EGFR ligand signaling in the EGFR autocrine cell line NCI-H1666 and can be used in combination with other anti-EGFR drugs such as gefitinib.
INCB3619 (2 µM) inhibits ERK1/2 expression in NCI-H1666 and make it sensitive to Gefitinib (HY-50895).

In Vivo: INCB3619 (subcutaneous injection, 60 mg/kg/d, 14 d) exhibits antitumor activity and sensitizes tumors to Gefitinib (HY-50895) in A549 xenografted BALB/c nu/nu mouse model.

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