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- 2025年12月05日
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Antitumor agent-88
CAS No. : 1422527-87-4
MCE 国际站：Antitumor agent-88
产品活性：Antitumor agent-88 表现出有效的抗有丝分裂活性并使细胞停滞在 G2/M 期。Antitumor agent-88 扰乱表达 CYP1A1 的乳腺癌细胞中的微管和细胞骨架。Antitumor agent-88 也是 CYP1A1 的竞争性抑制剂 (Ki: 1.4 μM)。
研究领域：Metabolic Enzyme/Protease
作用靶点：Cytochrome P450
In Vitro: Antitumor agent-88 (Compound 14, 48 h) inhibits MCF-7 cell growth, with an IC50 of 200 nM, and is inactive on MDA-MB-231 (IC50 >8600 nM).
Antitumor agent-88 inhibits MDA-MB-468, SK-BR cell growth with IC50s of 21 nM, 3.2 nM.
Antitumor agent-88 (50 nM, 48 h) causes accumulation of the cells in the G2/M phase by 42%.
Antitumor agent-88 shows high affinity for CYP1A1 (Ki: 1.4 μM).
Antitumor agent-88 selectively inhibits HT-1080 cell proliferation, with IC50s of 30 nM for HT-1080 transfected withCYP1A1.
In Vivo: Antitumor agent-88 (Compound 14) (1 μg/egg) shows antitumoral activities in the chick embryos bearing HT-1080CYP1A1 tumors.
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