DHFR-IN-5,1142407-81-5

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

DHFR-IN-5

CAS No. : 1142407-81-5

MCE 国际站：DHFR-IN-5

产品活性：DHFR-IN-5 是一种有效且具有口服活性的二氢叶酸还原酶 (DHFR) 抑制剂，对 Plasmodium falciparum 突变体的 K_i 值为 0.54 nM。DHFR-IN-5显示抗疟疾活性 ^[1]。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dihydrofolate reductase (DHFR)

In Vitro: DHFR-IN-5 (compound p218) shows highly active against PYR-resistant P. falciparum with IC₅₀s of 4.6, 56 nM for wild-type P. falciparum (TM4), quadruple mutant P. falciparum (V1/S), respectively.

In Vivo: DHFR-IN-5 (compound p218) (30 mg/kg; p.o.) shows anti-malaria activity with good oral bioavailability (46.3%), a reasonable half-life (7.3 h) in rats.

相关产品：WR99210  |  Trimetrexate  |  10-Deazaaminopterin  |  10-Formylfolic acid  |  4′-DTMP  |  DHFR-IN-11  |  DHFR-IN-12  |  DHFR-IN-4  |  DHFR-IN-8  |  DHFR-IN-9  |  EGFR/HER2/DHFR-IN-2  |  EGFR/HER2/DHFR-IN-3  |  Epiroprim  |  Metioprim  |  Talotrexin  |  VEGFR-2/DHFR-IN-1  |  VEGFR-2/DHFR-IN-2

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds