Anti-ADAM17(Cleaved-Arg215) Po

产品简介

英文名称	Anti-ADAM17(Cleaved-Arg215) Polyclonal Antibody
中文名称	肿瘤坏死因子α转换酶抗体
靶标	ADAM17(Cleaved-Arg215)
别名	ADAM 17;CD156b;CSVP;TACE;TNF-alpha convertase;TNF-alpha-converting enzyme;Snake venom-like protease;
背景资料	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820).
Swiss Prot	P78536
Gene ID	6868
亚细胞定位	Cytoplasm Cell membrane
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
蛋白分子量	79/93kDa
稀释比例	IHC 1:100-300.
免疫原	A synthetic peptide of human ADAM17(Cleaved-Arg215)
Public Immunogen Range	200-250/824aa
纯化方法	Affinity purification
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存	Store at -20°C. Avoid freeze / thaw cycles.
交叉反应	Human
应用	IHC
规格	50ul 100ul
单位	支

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Immunohistochemistry of paraffin-embedded Human colorectal cancer with ADAM17(Cleaved-Arg215) antibody diluted at 1:200.

Immunohistochemistry of paraffin-embedded Human endometrial cancer with ADAM17(Cleaved-Arg215) antibody diluted at 1:200.