生物素标记重组人Notch 1蛋白相关信息: 英文名称 Recombinant human Notch 1 protein, C-His-Avi (HEK293) / Biotin 中文名称 生物素标记重组人Notch 1蛋白 英文别名 EC 2.1.2.11; EC 3.4.21.68; Neurogenic locus notch homolog protein 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; hN1; Lin-12; LIN12; MIS6; Motch A; mT14; Neurogenic locus notch homolog protein 1; Neurogenic locus notch protein homolog; NICD; Notch1 intracellular domain; NOTC1_HUMAN; Notch 1; NOTCH; Notch gene homolog 1 (Drosophila); Notch homolog 1 translocation associated (Drosophila); Notch homolog 1, translocation-associated (Drosophila); NOTCH, Drosophila, homolog of, 1; p300; TAN 1; TAN1; Translocation Associated Notch Homolog; Translocation Associated Notch Homolog; Translocation associated notch protein TAN 1; Translocation-associated notch protein TAN-1; Recombinant human Notch 1 protein, C-His-Avi (HEK293) / Biotin 蛋白细胞定位 细胞核,细胞膜 分子量 271 浓度 >0.5 mg/ml 储存液 Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization. 保存条件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
生物素标记重组人Notch 1蛋白
背景资料:This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]. Notch 1蛋白是一个进化上保守的跨膜受体家族,广泛分布和表达在多个物种之中。研究发现Notchl作为一条信号转导途径,不仅对正常组织、细胞的分化、发育起重要作用,而且和一些肿瘤的发生和生长相关,有学者发现Notchl在许多实体瘤中异常表达,如:如宫颈癌、子宫内膜癌、肾癌、肺癌、乳腺癌、神经母细胞瘤等。因此Notchl作为一种预防和治疗肿瘤的新途径越来越受到人们的重视。