英文名称 Recombinant human CD80 protein, C-His-Avi (HEK293) 中文名称 重组人CD80/B7-1蛋白 英文别名 Activation B7-1 antigen; B lymphocyte activation antigen B7; B7; B7-1; B7-1 antigen; BB1; CD28 antigen ligand 1; CD28LG; CD28LG1; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 antigen; CD80 molecule; CD80_HUMAN; Costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80; Recombinant human CD80 protein, C-His-Avi (HEK293) 蛋白细胞定位 细胞膜 分子量 31 浓度 >0.5 mg/ml 储存液 Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization. 保存条件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
重组人CD80/B7-1蛋白
纯度 >95% as determined by Tris-Bis PAGE; >95% as determined by SEC-HPLC 内毒素 <1.0 EU/μg as determined by LAL 重组蛋白-表达系统 HEK293 cell
背景资料:CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.