英文名称 Recombinant HPV16 E6 protein, DsbC & His 中文名称 重组人类乳头状瘤病毒16-E6蛋白 英文别名 E6; HPV16 E6 protein; Human Papilloma Virus; Human papillomavirus type 16 E6; Human papillomavirus type 16; Protein E6; E6 protein; HPV16 E6; HPV16-E6; VE6_HPV16; Recombinant HPV16 E6 protein, DsbC & His 蛋白细胞定位 分子量 11 浓度 >0.5 mg/ml 储存液 20 mM Tris-HCl (pH=8.0) 保存条件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
重组人类乳头状瘤病毒16-E6蛋白
背景资料:Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. E7/E6protein抗体主要用于性病及妇科肿瘤方面的研究,HPV16是宫颈癌的主要致癌病毒,也用于与HPV有关的各种肿瘤的研究。表达位置:胞核。阳性细胞也可见于角蛋白层,尤其是在疣中。该抗体用于人类生殖系统传染性疾病及其肿瘤的研究,亦可用于食管癌、乳腺癌等恶性肿瘤的研究。