A0A240EUK5_9INFA; Neuraminidase · Influenza A virus (A/oriental magpie robin/HK/6154/2015(H5N6)); Neuraminidase; NA; GenBank: AOC37464.1; Recombinant H5N6-NA protein, His
理论分子量
50kDa
检测分子量
55 kDa
性 状
Lyophilized or Liquid
浓 度
>0.5 mg/ml
物 种
IAV
序 列
2-459/459
纯 度
>95% as determined by SDS-PAGE
纯化方法
AC
内毒素
Not analyzed
表达系统
E.coli
活性
Not tested
标签
His
缓 冲 液
20 mM Tris-HCl (pH=8.0) with 150 mM NaCl
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
重组H5N6-NA蛋白
产品介绍:Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.