- ￥3794
- SIGMA
- 美国
- MSQC21-100UG
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
SIGMA
- 库存：
999
- 供应商：
麦格生物
- 规格：
MSQC21-100UG
说明
一般描述
SILu™MAb Bevacizumab (MSQC21) is a recombinant, stable isotope-labeled, monoclonal antibody which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, it is designed to be used as an internal standard for the quantitative mass spectrometry analysis of Bevacizumab in human serum.
SILu™MAb Bevacizumab is for R&D use only. Not for drug, household, or other uses.
序列
SILu™MAb Cetuximab Heavy Chain:
QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
SILu™MAb Cetuximab Light Chain:
DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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文献和实验Restoration of the molecular clock is tumor suppressive in neuroblastoma.
Determination of the Immunoreactivity of Radiolabeled Monoclonal Antibodies
site of the antibody, radiometals may not be the most appropriate isotope to use. However, the antibody is likely to contain a number of tyrosine and lysine residues that can be labeled, so the reduction in immunoreactivity caused by radiolabeling
【翻译】Development trends for monoclonal antibody cancer therapeutics
has not yet been resolved; downmodulation of HER2-mediated signalling and increased tumour-cell apoptosis have been proposed in addition to recruitment of ADCC35, 36. One approved unmodified mAb — bevacizumab (Avastin; Genentech/Roche) — binds to the ligand vascular
ELISA原理与实验方法The advantages of the ELISA are similar to other antibody-labeled reactions which include specificity, sensitivity, inexpensiveness, and safety. Since the enzyme label is the critical portion of ELISA, its selection is very important
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