70372 SIGMA 1,4-萘醌

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1,4-萘醌

purum, ≥96.5% (HPLC)
_{别名:
α-萘醌
Empirical Formula (Hill Notation):
C10H6O2}

应用

1,4-Naphthoquinone is the key structural moiety of many anticancer and antifungal agents.[1]
It can be used to synthesize:[2]

• 3,3-Disubstituted oxindoles via asymmetric Michael addition to oxindole.
• Bioactive isoindolines via asymmetric 1,3-dipolar cycloaddition to azomethine ylides generated in situ from aldehydes and diethyl aminomalonate.
• α,α-Difluoro-β-hydroxy ketone via ‘on water′ catalyst-free Mukaiyama-aldol reaction with difluoroenoxysilane.
• 2-Hydroxy-3-anilino-1,4-naphthoquinone, which shows potent in vivo antimalarial activity.

Additional appilcation include:[2]

• As an arylation reagent for the α-arylation of aldehydes.
• As a starting material in the multi-step synthesis of benz[f]indole-4,9-diones.