Anti-NAG-1 (RABBIT) Antibody Peroxidase Conjugated - 209-403-B88,抗NAG-1(兔)抗体过氧化物酶结合物-209-403-B88,抗NAG-1(兔)抗体过氧化物酶结合物-209-403-B88,Anti-NAG-1 (RABBIT) Antibody Peroxidase Conjugated - 209-403-B88
产品名称:抗NAG-1(兔)抗体过氧化物酶结合物-209-403-B88-Anti-NAG-1 (RABBIT) Antibody Peroxidase Conjugated - 209-403-B88
产品货号:209-403-B88
产品规格:100ug
应用类型:ELISA,Western Blot,
保存建议:抗NAG-1(兔)抗体过氧化物酶结合物-209-403-B88-Anti-NAG-1 (RABBIT) Antibody Peroxidase Conjugated - 209-403-B88Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
背景资料:Non-steroidal anti-inflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1), Growth Differentiation Factor 15 (GDF15), Placental Bone Morphogenetic Protein (PLAB), or Prostate Derived Factor (PDF). NAG-1 is expressed in human placenta, prostate and colon. It possesses antitumorigenic and proapoptotic activities. NAG-1 expression is dramatically increased in inflammation, injury and malignancy. Increase of NAG-1 expression is a feature of many cancers including breast, colon, pancreas and prostate. In a number of studies, NAG-1 expression was increased by a number of NSAIDs. This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers. NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, indoles, epicatechin gallate, and genistein. Induced expression of NAG-1 results in stimulation of apoptosis and inhibition of cell growth. Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis. NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1. EGR-1 may be necessary for NSAID-induced NAG-1 expression. The study of expression of NAG-1 proteins, including variants, is important to define their potential role as serum biomarkers for cancer diagnosis, treatment monitoring, epidemiology study, and nutrition surveys.
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