Anti-Histone H4 [p Ser1] (RABBIT) Antibody - 600-401-I96,抗组蛋白H4[pSer1](兔)抗体-600-401-I96,抗组蛋白H4[pSer1](兔)抗体-600-401-I96,Anti-Histone H4 [p Ser1] (RABBIT) Antibody - 600-401-I96
产品名称:抗组蛋白H4[pSer1](兔)抗体-600-401-I96-Anti-Histone H4 [p Ser1] (RABBIT) Antibody - 600-401-I96
产品货号:600-401-I96
产品规格:50ug
应用类型:Chip,Immunohistochemistry,IF Microscopy,Western Blot,
保存建议:抗组蛋白H4[pSer1](兔)抗体-600-401-I96-Anti-Histone H4 [p Ser1] (RABBIT) Antibody - 600-401-I96Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
背景资料:Chromatin is the arrangement of DNA and proteins in which chromosomes are formed. Correspondingly, chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is a very dynamic structure in which numerous post-translational modifications work together to activate or repress the availability of DNA to be copied, transcribed, or repaired. These marks decide which DNA will be open and commonly active (euchromatin) or tightly wound to prevent access and activation (heterochromatin). Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. In particular, phosphorylation of H4 Ser1 (H4 pS1) has been linked to mitosis and DNA repair. This modification is enriched in sites proximal to double stranded brakes, but not those associated with UV damage. Casein kinase II (CK2) phosphorylates H4 Ser1, and it also implicated in regulating the DNA damage response. Furthermore, recruitment of CK2 requires the SIN3/RPD3 histone deacetylase complex. Anti-Histone H4 are ideal for researchers interested in DNA Repair, Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, DNA replication Transcription Translation and Splicing, and Epigenetics research.
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Rockland成立于1962年,是一家老牌抗体原产企业,其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体,包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素(Ubiquitin)等识别抗体,应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外,Rockland也生产特别齐全的二抗,包括纯化、生物素、HRP/ALP、荧光标记二抗,应用十分广泛。
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