Anti-Cripto-1 (TDGF1) (RABBIT) Antibody - 600-401-997,Anti-Cripto-1(TDGF1)(RABBIT)Antibody-600-401-997,Anti-Cripto-1(TDGF1)(RABBIT)Antibody-600-401-997,Anti-Cripto-1 (TDGF1) (RABBIT) Antibody - 600-401-997
产品名称:Anti-Cripto-1(TDGF1)(RABBIT)Antibody-600-401-997-Anti-Cripto-1 (TDGF1) (RABBIT) Antibody - 600-401-997
产品货号:600-401-997
产品规格:100ug
应用类型:ELISA,Immunohistochemistry,Western Blot,
保存建议:Anti-Cripto-1(TDGF1)(RABBIT)Antibody-600-401-997-Anti-Cripto-1 (TDGF1) (RABBIT) Antibody - 600-401-997Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
背景资料:This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor b (TGFb) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.
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