Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
产品名称:STUB1(CHIP)重组蛋白-HIS表位-009-001-T64S-【干冰】STUB1 (CHIP) recombinant protein-HIS Epitope-009-001-T64S
产品货号:009-001-T64S
产品规格:20ug
来源宿主:该STUB1(CHIP)重组蛋白-HIS表位-009-001-T64S的详细信息查看Rockland提供的产品说明。
保存建议:STUB1(CHIP)重组蛋白-HIS表位-009-001-T64S-【干冰】STUB1 (CHIP) recombinant protein-HIS Epitope-009-001-T64SStore product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
背景资料:CHIP (STUB1) or STIP1 homology and U-box containing protein 1 (also known as E3 ubiquitin protein ligase) is an ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (1). CHIP acts as a molecular switch for the degradation of misfolded proteins via the proteasome and lysosome pathways (2). CHIP controls the cellular level of BER enzymes and, correspondingly, the efficiency and capacity of BER. CHIP E3 ubiquitin ligases act sequentially in ER membrane and cytosol to monitor the folding status of CFTR and delF508.CHIP possesses intrinsic E3 ubiquitin ligase activity and promotes ubiquitylation. STUB1 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, and Metabolic Disorder research.
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